Sodium-oxybate
نویسندگان
چکیده
منابع مشابه
Sodium Oxybate for Narcolepsy
1a. Is sodium oxybate safe and clinically effective in the reduction in number and intensity of cataplexy attack, excessive day-time sleepiness (diurnal naps), nocturnal awakenings, terrifying dream experiences, insomnia, hypnagogic hallucinations, sleep paralysis, and improvement in quality of life in adult patients with narcolepsy and cataplexy compared to no intervention, combined treatment ...
متن کاملDifferential Effects of Sodium Oxybate and Baclofen
1071 GABAB Agonist, Sleep, and the EEG—Vienne et al INTRODUCTION Sodium oxybate (SO, sodium salt of γ-hydroxybutyric acid [GHB]) is an endogenously produced fatty acid, recently approved for the treatment of narcolepsy with cataplexy.1 GHB has been shown to increase slow wave sleep (SWS) and EEG delta power (0.75-4.5 Hz), in a dose-dependent manner in healthy subjects2-4 and in patients with na...
متن کاملPsychosis in the context of sodium oxybate therapy.
Sodium oxybate (brand name Xyrem) is a sodium salt of gamma-hydroxybutyric acid (GHB), an endogenous CNS depressant, which is an effective treatment of narcolepsy. As a drug of abuse, GHB produces severe psychiatric side effects and withdrawal. However, there are no reports of these effects when using clinically recommended doses. This paper presents a case of a patient who developed altered me...
متن کاملSodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience.
Sodium oxybate (SO; Xyrem®) has been approved in most countries for treatment of narcolepsy and cataplexy. In this study, we present a single-center experience of a series of 18 patients with narcolepsy with cataplexy (18/18 DQB1*0602 positive, 17/17 with low/absent cerebrospinal fluid hypocretin) in whom SO was prescribed. After 26 ± 13 months, 13/18 patients were still on SO at a mean dosage ...
متن کاملGlucose and Fat Metabolism in Narcolepsy: Effect of Sodium Oxybate
795 Glucose and Fat Metabolism in Narcolepsy—Donjacour et al INTRODUCTION Narcolepsy is a sleep disorder that is characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, sleep paralysis, disturbed nocturnal sleep and obesity.1 Both obesity and disturbed nocturnal sleep are important risk factors for the development of type 2 diabetes mellitus (T2DM).2 Narcolepsy is c...
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ژورنال
عنوان ژورنال: Reactions Weekly
سال: 2021
ISSN: ['1179-2051', '0114-9954']
DOI: https://doi.org/10.1007/s40278-021-95299-x